GLIS3 REGULATES TRANSCRIPTION OF THYROID HORMONE BIOSYNTHETIC GENES IN COORDINATION WITH OTHER THYROID TRANSCRIPTION FACTORS

GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors

Abstract Background Loss of the transcription factor GLI-Similar 3 (GLIS3) function causes congenital hypothyroidism (CH) in both humans and mice due to decreased expression of several thyroid hormone (TH) biosynthetic genes in thyroid follicular cells.Whether and to what extent, GLIS3 regulates thyroid gene transcription in coordination with other

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Impact of Material Stiffness and Anisotropy on Coaptation Characteristics for Aortic Valve Cusps Reconstructed from Pericardium

The numerical assessment of reconstructed aortic valves competence and leaflet design optimization rely on both coaptation characteristics and the diastolic valve configuration.These characteristics can be evaluated by the shell or membrane formulations.The membrane formulation is preferable for surgical aortic valve neocuspidization planning since

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